Per-Mikael Aberg

Title: Per-Mikael Aberg: Innovator in Chromatography Ligands

Introduction

Per-Mikael Aberg is a notable inventor based in Uppsala, Sweden. He has made significant contributions to the field of chromatography, particularly in the isolation of antibodies. With a total of 12 patents to his name, Aberg's work has advanced the capabilities of bioprocessing technologies.

Latest Patents

One of Aberg's latest patents is titled "Chromatography ligand comprising domain C from protein A for antibody isolation." This invention relates to a chromatography ligand that includes Domain C from protein A (SpA), or a functional fragment or variant thereof. The chromatography ligand is designed to withstand harsh cleaning in place (CIP) conditions and is capable of binding Fab fragments of antibodies. Additionally, the ligand can be equipped with a terminal coupling group, such as arginine or cysteine, to facilitate its attachment to an insoluble carrier like beads or a membrane. The invention also encompasses a process for using the ligand in antibody isolation and a purification protocol that may involve washing steps and/or regeneration with alkali.

Career Highlights

Throughout his career, Aberg has worked with prominent companies in the biopharmaceutical sector. He has been associated with GE Healthcare Bio-Sciences AB and Cytiva Bioprocess R&D AB. His work in these organizations has contributed to the development of innovative solutions in bioprocessing and chromatography.

Collaborations

Aberg has collaborated with several professionals in his field, including Gustav Jose Rodrigo and Martin Hall. These collaborations have likely enhanced the scope and impact of his inventions.

Conclusion

Per-Mikael Aberg is a distinguished inventor whose work in chromatography has significantly influenced antibody isolation techniques. His innovative patents and collaborations reflect his commitment to advancing bioprocessing technologies.