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Years Active: 2013-2016
Title: Peillin Yu: Innovator in Oligonucleotide Synthesis
Introduction
Peillin Yu is a notable inventor based in Houston, TX (US). He has made significant contributions to the field of oligonucleotide synthesis, holding 2 patents that showcase his innovative methods and techniques.
Latest Patents
One of Peillin Yu's latest patents focuses on "Linkers and co-coupling agents for optimization of oligonucleotide synthesis and purification on solid supports." This patent describes a method for modulating the synthesis capacity and cleavage properties of synthetic oligomers from solid support. The method utilizes linker molecules attached to a solid surface and co-coupling agents that exhibit similar reactivities to the coupling compounds with the surface functional groups. The preferred linker molecules enhance the density of polymers and increase resistance to cleavage from the support surface. This method is particularly beneficial for the synthesis of oligonucleotides, oligonucleotide microarrays, peptides, and peptide microarrays. The stable linkers are also coupled to anchor molecules for the synthesis of DNA oligonucleotides using on-support purification, which eliminates the need for time-consuming chromatography and the presence of metal cations. The oligonucleotides produced can be directly utilized for mass analysis, DNA amplification and ligation, hybridization, and various other applications.
Career Highlights
Peillin Yu has worked at prestigious institutions, including the University of Michigan and the University of Houston System. His experience in these academic environments has contributed to his expertise in the field of oligonucleotide synthesis.
Collaborations
Peillin Yu has collaborated with notable colleagues, including Xiaolian Gao and Hua Zhang. Their combined efforts have further advanced research in the area of oligonucleotide synthesis.
Conclusion
Peillin Yu's innovative work in oligonucleotide synthesis and purification has made a significant impact in the field. His patents and collaborations reflect his dedication to advancing scientific research and technology.