Peike Sheng

Title: Peike Sheng: Innovator in RNA Interference Technology

Introduction

Peike Sheng is a notable inventor based in Gainesville, FL (US). He has made significant contributions to the field of molecular biology, particularly in the area of RNA interference. His innovative work has the potential to impact therapeutic strategies for various diseases.

Latest Patents

Peike Sheng holds a patent for "miRNA switches for RNA-triggered control of RNA interference." This patent describes methods, compositions, and systems that utilize synthetic nucleic acid molecules to enable inducible or conditional pri-miRNA processing in mammalian cells in vivo. The technology, referred to as Orthogonal RNA Interference induced by Trigger RNA (ORIENTR), allows for the switching between inactive and active forms upon interaction with specific RNA-trigger molecules. This interaction facilitates the formation of a correctly folded pri-miRNA scaffold substrate, which can be processed by proteins of the RNAi pathway, leading to the repression of target genes. The methods outlined in the patent also include applications for disease treatment and detection of target RNA in biological samples.

Career Highlights

Throughout his career, Peike Sheng has worked with prestigious institutions such as Boston University and the University of Florida Research Foundation. His research has focused on advancing the understanding and application of RNA interference technologies.

Collaborations

Peike Sheng has collaborated with notable colleagues, including Alexander A Green and Yu Zhou. Their combined expertise has contributed to the development of innovative solutions in the field of RNA research.

Conclusion

Peike Sheng's contributions to RNA interference technology exemplify the impact of innovative thinking in addressing complex biological challenges. His work continues to pave the way for advancements in therapeutic applications and molecular biology.