Paula M Kinnunen

Title: Paula M Kinnunen: Innovator in Cholesterol Esterase Research

Introduction

Paula M Kinnunen is a notable inventor based in University City, MO (US). She has made significant contributions to the field of biochemistry, particularly in the area of cholesterol absorption and enzyme purification. With a total of 3 patents, her work has implications for both human health and medical research.

Latest Patents

Kinnunen's latest patents include a method for recovering a purified 100,000 dalton molecular weight fraction. This method details how intestinal cell endogenous heparin can mediate the absorption of cholesterol or fatty acids in mammals. The patent explains that the oral administration of heparin, an active heparin subfraction, or heparinase can inhibit the suppression of cholesterol esterase-mediated absorption in humans. The process involves several steps, including the preparation of a solution of dialyzed human pancreatic cytosol, passing it over a hydroxyapatite column, and utilizing gel filtration to collect the esterase as a single peak.

Career Highlights

Throughout her career, Kinnunen has worked with various organizations, including Cv Therapeutics, Inc. Her research has focused on the mechanisms of cholesterol absorption and the role of enzymes in this process. Her innovative methods have contributed to a better understanding of how to manage cholesterol levels in humans.

Collaborations

Kinnunen has collaborated with notable colleagues such as Curtis A Spilburg and Louis G Lange, III. These partnerships have enhanced her research and expanded the impact of her findings in the scientific community.

Conclusion

Paula M Kinnunen's work in the field of cholesterol esterase research showcases her innovative spirit and dedication to advancing medical science. Her patents reflect her commitment to improving human health through scientific discovery.