Location History:
- Secaucus, NJ (US) (1994 - 2000)
- Rutherford, NJ (US) (1988 - 2002)
Company Filing History:
9 out of 1,829 
1 out of 28 
3 out of 832,843 Years Active: 1988-2002
Title: The Innovations of Paul P Trotta
Introduction
Paul P Trotta is a notable inventor based in Rutherford, NJ (US), recognized for his contributions to the field of biotechnology. With a total of 13 patents to his name, Trotta has made significant advancements in the understanding and application of antibody antagonists and crystallization methods for macromolecules.
Latest Patents
One of Trotta's latest patents is focused on antibody antagonists of human interleukin-4. This invention provides two types of antibody antagonists that inhibit the binding of human IL-4 to its cellular receptors. Some antagonists bind to specific regions of IL-4, which are believed to be crucial for its interaction with receptors. This specific binding effectively inhibits the binding of IL-4 to the receptors. Additionally, the invention includes anti-idiotypic antibodies that mimic IL-4 and compete for binding to the cellular receptors, despite lacking IL-4 activity. The patent also outlines polypeptides used to create these antibody antagonists and methods for utilizing them to inhibit IL-4 binding.
Another significant patent by Trotta is a method and apparatus for crystallizing macromolecules in microgravity. This innovative apparatus includes a container made of low thermal conductivity material with a thermally conductive lid. A heat source is in thermal contact with the lid to create a temperature gradient within the container. This gradient is essential for controlling the crystallization of macromolecules when a solution is placed inside. The method involves a temperature ramp to maintain and control the temperature gradient, facilitating the crystallization process.
Career Highlights
Throughout his career, Trotta has worked with various organizations, including Schering Corporation. His work has significantly impacted the fields of biotechnology and pharmaceuticals, leading to advancements in therapeutic applications.
Collaborations
Trotta has collaborated with notable individuals in his field, including Paul Reichert and Tattanahalli L Nagabhushan. These collaborations have contributed to the development of innovative solutions in biotechnology.
Conclusion
Paul P Trotta's contributions to the field of biotechnology through his patents and collaborations highlight his role as a significant inventor. His work continues to influence advancements in medical and scientific research.