Paul N Reynolds

Title: Paul N Reynolds - Innovator in Gene Therapy

Introduction

Paul N Reynolds is a notable inventor based in Birmingham, Alabama. He has made significant contributions to the field of gene therapy, particularly through his innovative approaches to gene expression control. His work focuses on developing strategies that enhance the safety and efficacy of gene therapies.

Latest Patents

Reynolds holds a patent for a tissue-specific self-inactivating gene therapy vector. This invention provides a strategy that allows for selective switching off of both transgene and viral gene expression in tissues where such expression is undesirable. The patent employs a vector containing a tissue-specific promoter that drives the expression of the Cre recombinase gene in tissues where transgene expression is not wanted. As a result of Cre recombinase expression, the same or another vector that expresses the transgene in that tissue will be cut into several pieces due to LoxP sites strategically placed within the vector backbone. Consequently, unwanted transgene and viral gene expression are effectively prevented.

Career Highlights

Reynolds is associated with the UAB Research Foundation, where he continues to advance his research in gene therapy. His work has garnered attention for its potential applications in treating various genetic disorders.

Collaborations

One of his notable collaborators is David T Curiel, with whom he has worked on various projects related to gene therapy and vector development.

Conclusion

Paul N Reynolds is a pioneering inventor whose work in gene therapy is paving the way for safer and more effective treatments. His innovative patent demonstrates a significant advancement in the field, showcasing his commitment to improving healthcare through scientific research.