Paul Mccray

Title: The Innovations of Paul McCray

Introduction

Paul McCray is a notable inventor based in Iowa City, IA, who has made significant contributions to the field of genetic engineering. He holds three patents that showcase his innovative approach to solving complex biological problems. His work primarily focuses on developing methods to repair genetic defects and enhance viral vector production.

Latest Patents

One of McCray's latest patents is titled "Zinc finger nuclease for the CFTR gene and methods of use thereof." This invention provides new zinc finger proteins and zinc finger nucleases (ZFNs) that are particularly useful in repairing the cystic fibrosis transmembrane conductance regulator (CFTR) gene. Another significant patent is related to "Baculoviruses with enhanced virion production and a method for the production of baculoviruses." This method involves co-expressing a portion of the VSV G protein gene or a truncated 'stem' portion with GP64 and a retrovirus, which increases the titer of retroviral vectors. The preferred embodiment of this invention uses a VSV G construct that includes specific segments from the C-terminal portion of the ectodomain, the transmembrane domain, and the cytoplasmic tail domains of the VSV G protein.

Career Highlights

Throughout his career, Paul McCray has worked with esteemed organizations such as the University of Iowa Research Foundation and The General Hospital Corporation. His contributions to these institutions have been instrumental in advancing research in genetic therapies and viral vector technology.

Collaborations

McCray has collaborated with notable colleagues, including Patrick Sinn and Morgan Maeder, who have contributed to his research endeavors and innovations.

Conclusion

Paul McCray's work exemplifies the spirit of innovation in the field of genetic engineering. His patents reflect a commitment to addressing critical health challenges through scientific advancements.