Location History:
- Flagstaff, AZ (US) (2001)
- Silver Spring, MD (US) (1999 - 2002)
Company Filing History:
1 out of 1,039 
3 out of 832,843 Years Active: 1999-2002
Title: Paul F. Torrence: Innovator in Molecular Therapeutics
Introduction
Paul F. Torrence is a distinguished inventor based in Silver Spring, MD (US). He has made significant contributions to the field of molecular therapeutics, holding a total of 4 patents. His work primarily focuses on innovative approaches to treat malignancies through the modulation of telomerase activity.
Latest Patents
Among his latest patents, Torrence has developed RNase L activators and antisense oligonucleotides effective in treating telomerase-expressing malignancies. This invention involves chimeric molecules that comprise an oligonucleotide complementary to a region of the ribonucleotide component of telomerase, attached to an activator of RNase L. These activator-antisense complexes specifically cleave the ribonucleotide portion of the telomerase enzyme, providing a method to inhibit telomerase enzymatic activity. Furthermore, he has also created chimeric molecules targeted to viral RNAs, which consist of a virus-targeting antisense oligonucleotide moiety linked to an activator of 2-5A-dependent RNase.
Career Highlights
Throughout his career, Torrence has worked with notable institutions, including The Cleveland Clinic Foundation. His innovative research has paved the way for new therapeutic strategies in oncology, particularly in targeting telomerase activity in malignant cells.
Collaborations
Torrence has collaborated with esteemed colleagues such as Robert H. Silverman and Guiying Li, contributing to the advancement of molecular therapeutics.
Conclusion
Paul F. Torrence's work exemplifies the intersection of innovation and medical science, showcasing his commitment to developing effective treatments for serious health conditions. His contributions continue to influence the field of molecular therapeutics significantly.