Paul Eugene Lund

Title: Paul Eugene Lund: Innovator in Nucleic Acid Processing

Introduction

Paul Eugene Lund is a notable inventor based in San Leandro, CA. He has made significant contributions to the field of nucleic acid processing, holding 2 patents that showcase his innovative approaches to biotechnology.

Latest Patents

Lund's latest patents include "Methods and systems for reducing artifactual antisense products." This patent discloses a method aimed at preventing the amplification of artifactual antisense products during the sequencing of target polynucleotides. By incorporating modified nucleotides into handle polynucleotide sequences, the method allows for the selective degradation of artifact antisense products generated by mis-priming before amplification. This process ensures that these artifacts do not appear in the amplification library. The selective degradation can be achieved using agents specifically designed to cleave the handle polynucleotide at the modified nucleotide. Amplification is performed using a primer that hybridizes to the handle sequence and a second primer that targets a complement of a specific nucleotide.

Another significant patent is "Probe-based analysis of nucleic acids and proteins." This patent provides systems and methods for processing biomolecules, such as nucleic acids and proteins, from samples. The method involves hybridizing a probe molecule to a target region of a nucleic acid molecule, such as RNA, and barcoding the probe-nucleic acid complex. The process may include various nucleic acid reactions, including extension, denaturation, and amplification. Additionally, the method allows for hybridizing probes to target regions of nucleic acids and reporter oligonucleotides, facilitating the barcoding of probe-associated molecules.

Career Highlights

Paul Lund is currently employed at 10x Genomics, Inc., where he continues to advance his research and development in the field of genomics. His work has been instrumental in enhancing the accuracy and efficiency of nucleic acid analysis.

Collaborations

Lund collaborates with talented individuals such as Katherine Pfeiffer and Andrew Kohlway, contributing to a dynamic research environment that fosters innovation and discovery.

Conclusion

Paul Eugene Lund is a distinguished inventor whose work in nucleic acid processing has led to significant advancements in biotechnology. His patents reflect a commitment to improving methodologies in the field, making him a valuable contributor to scientific research and innovation.