Company Filing History:
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Years Active: 1995-2010
Title: Paul E Mayrand: Innovator in PCR Technologies
Introduction
Paul E Mayrand is an accomplished inventor based in Pacifica, CA, USA, known for his significant contributions to the field of molecular biology. With a remarkable portfolio of 7 patents, he has focused on developing innovative methods that advance PCR (Polymerase Chain Reaction) techniques, which are essential for genetic analysis and diagnostics.
Latest Patents
One of his latest patents addresses "Methods and Reagents for Combined PCR Amplification." This invention involves an oligonucleotide probe designed with a fluorescer molecule attached to one end and a quencher molecule on the opposite end. The unique construction of the probe allows it to be impervious to digestion by the 5'→3' exonuclease activity of a polymerase, as well as preventing degradation during the polymerase’s 5'→3' extension. The patent outlines methods for performing combined PCR amplification and hybridization probing, where specific steps include contacting a target nucleic acid sequence with PCR reagents and the oligonucleotide probe followed by thermal cycling. Further refinements of this method introduce a strand displacer to enhance amplification efficiency. Additionally, alternative combined PCR hybridization methods are described that do not require probes with protected 5' ends.
Career Highlights
Throughout his career, Paul E Mayrand has worked with notable companies, including PerkinElmer Corporation and Applied Biosystems Division. His experiences at these organizations have provided him with substantial exposure to research and development in biotechnology.
Collaborations
Paul has collaborated with renowned colleagues such as G Richard Cathcart and Thomas Brennan-Marquez. Working alongside such experienced professionals has allowed him to refine his techniques and broaden his contributions to the scientific community.
Conclusion
Paul E Mayrand's innovative work in the development of PCR methods illustrates his expertise and dedication to improving molecular biology tools. With his extensive patent portfolio, he continues to influence advancements in genetic research and diagnostics, establishing himself as a valuable inventor in the field.