Company Filing History:
Years Active: 1995-1996
Title: Paul E Bliem: Innovator in Bile Acid Sequestration
Introduction
Paul E Bliem is a notable inventor based in Pottstown, PA (US). He has made significant contributions to the field of polymer chemistry, particularly in the development of bile acid sequestrant polymer compositions. With a total of 3 patents to his name, Bliem's work has the potential to impact pharmaceutical applications significantly.
Latest Patents
Bliem's latest patents focus on crosslinked anion exchange particles and methods for producing new bile acid sequestrant polymer compositions. These polymers are designed to be prepared in particulate form, preferably in spherical form. The innovative process involves crosslinking an amine-containing polymer with a polyfunctional amine-reactive compound. This results in a polymer that is essentially water insoluble and exhibits bile acid sequestering efficacy greater than that of cholestyramine, ideally exceeding three times its efficacy. The polymerization process utilizes suspension polymerization of water-soluble amine-containing monomers, such as dialkylaminoalkyl (meth)acrylate esters and dialkylaminoalkyl (meth)acrylamides, in the presence of polyfunctional amine-reactive compounds like substituted dihaloalkanes. Additionally, Bliem's patents describe pharmaceutical compositions containing these bile acid sequestrant polymer particles and methods for lowering blood cholesterol levels using these compositions.
Career Highlights
Paul E Bliem is associated with Rohm and Haas Company, where he has been instrumental in advancing research in polymer applications. His innovative work has garnered attention in the scientific community, particularly for its implications in health and medicine.
Collaborations
Bliem has collaborated with notable professionals in his field, including his coworker Larry W Steffier. Their combined expertise has contributed to the successful development of new polymer technologies.
Conclusion
Paul E Bliem's contributions to the field of polymer chemistry, particularly in bile acid sequestration, highlight his innovative spirit and dedication to improving health outcomes. His work continues to pave the way for advancements in pharmaceutical applications.