Paul David Toman

Title: Paul David Toman: Innovator in Recombinant Collagen Production

Introduction

Paul David Toman is a notable inventor based in Mountain View, CA (US). He has made significant contributions to the field of biotechnology, particularly in the production of collagen through innovative methods involving transgenic mammals. With a total of 2 patents, Toman's work has the potential to impact various medical and therapeutic applications.

Latest Patents

Toman's latest patents include groundbreaking inventions. The first patent focuses on the production of collagen in the milk of transgenic mammals. This invention provides a method for creating transgenic nonhuman mammals that can secrete exogenous procollagen or collagen into their milk. These mammals are healthy and capable of producing procollagen or collagen at high levels, typically in trimeric form. The patent also outlines suitable transgenes for incorporation into these mammals.

The second patent involves mutated recombinant collagens. This invention presents recombinant procollagen chains that have a natural collagen chain separated from one or two propeptides by one or two non-natural site-specific proteolytic agent recognition sites. A variety of propeptides and site-specific proteolytic agent recognition sites can be utilized. The selection of specific site-specific proteolytic agent/recognition site pairs is based on various factors, including the conformation of the resulting procollagen and the compatibility of the proteolysis with the production of mature collagen.

Career Highlights

Throughout his career, Paul David Toman has worked with various companies, including Cohesion Technologies, Inc. His innovative work in biotechnology has positioned him as a key figure in the field.

Collaborations

Toman has collaborated with notable individuals such as Richard A Berg and Donald G Wallace. These collaborations have likely contributed to the advancement of his research and inventions.

Conclusion

Paul David Toman's contributions to the field of biotechnology, particularly in collagen production, showcase his innovative spirit and dedication to advancing medical science. His patents reflect a commitment to developing new methods that could lead to significant therapeutic applications.