Company Filing History:
Years Active: 1986
Title: Paul C Bossle: Innovator in High Performance Liquid Chromatography
Introduction
Paul C Bossle is a notable inventor based in Baltimore, MD (US). He has made significant contributions to the field of analytical chemistry, particularly in the area of high performance liquid chromatography (HPLC). His innovative methods have advanced the detection and analysis of chemical compounds, showcasing his expertise and dedication to scientific progress.
Latest Patents
Paul C Bossle holds a patent for a method titled "High performance liquid chromatography (HPLC) analysis of sulfur." This method allows for the simultaneous detection, separation, and analysis of sulfur mustard type compounds and their major hydrolysis and oxidation by-products. The innovative approach utilizes a novel precolumn enhancement derivatization procedure, which involves the reaction of nonchromophoric sulfides with N-halogeno-N-metal arylsulfonamidates on a microscale. This reaction produces UV or visible absorbing or fluorescing arylsulfonylsulfilimine compounds, which can be effectively separated on a low polarity C-18 column by reverse phase HPLC. The method is capable of quantifying these sulfides in quantities as small as 20 nanograms, demonstrating its sensitivity and efficiency.
Career Highlights
Paul C Bossle is currently employed by the US Government as represented by the Secretary of the Army. His work has been instrumental in developing analytical techniques that enhance the safety and effectiveness of chemical analysis in various applications. His dedication to research and innovation has positioned him as a key figure in his field.
Collaborations
Throughout his career, Paul has collaborated with esteemed colleagues, including John J Martin and Emory W Sarver. These partnerships have fostered a collaborative environment that encourages the exchange of ideas and advancements in analytical chemistry.
Conclusion
Paul C Bossle's contributions to high performance liquid chromatography exemplify the impact of innovative thinking in scientific research. His patented methods not only enhance the detection and analysis of critical compounds but also reflect his commitment to advancing the field of chemistry.