Paul A DiMilla

Title: Innovations by Paul A DiMilla

Introduction

Paul A DiMilla is a notable inventor based in Dover, MA (US), recognized for his contributions to the field of cell culture and organ assist technologies. With a total of six patents to his name, DiMilla has made significant advancements that enhance the functionality and efficiency of bioreactors and cell-culturing systems.

Latest Patents

One of his latest patents is titled "Chamber with adjustable volume for cell culture and organ assist." This invention features modular chambers designed for culturing cells, allowing the volume of a chamber to be adjusted without compromising its seal or sterility. The design is based on the principle of using a compressible gasket and a substantially incompressible stop, enabling the culture of cells in a controlled environment. This innovation is particularly beneficial for organ assist systems, as it allows for the culture of cells with high functionality while maintaining liquid-tightness and sterility.

Another significant patent is "In vivo induction for enhanced function of isolated hepatocytes." This invention involves a liver cell culture comprising hepatocytes that exhibit increased detoxification enzyme activity when isolated from a donor liver that has been treated with an induction agent. The induced hepatocytes are utilized in a bioreactor, which is integral to a liver assist device aimed at treating patients in need of liver support.

Career Highlights

Throughout his career, Paul A DiMilla has worked with various companies, including Organogenesis, Inc. His work has focused on developing innovative solutions that address critical challenges in cell culture and organ assist technologies.

Collaborations

DiMilla has collaborated with notable professionals in his field, including Maury D Cosman and Susan J Sullivan. These collaborations have contributed to the advancement of his inventions and the overall progress in the field of bioreactor technology.

Conclusion

Paul A DiMilla's innovative contributions to cell culture and organ assist technologies have significantly impacted the medical and biotechnological fields. His patents reflect a commitment to enhancing the functionality of bioreactors and improving patient care through advanced cell-culturing methods.