Company Filing History:
Years Active: 2002-2014
Title: The Innovative Contributions of Patrizia Castoldi
Introduction
Patrizia Castoldi is a notable inventor based in Lainate, Italy. She has made significant contributions to the field of pharmaceutical chemistry, particularly in the synthesis of important compounds. With a total of 2 patents to her name, her work has had a considerable impact on drug development.
Latest Patents
One of her latest patents is a process for the preparation of lacosamide. This novel process utilizes D,L-serine as a starting material, where the methylation reaction of hydroxyl is conducted using an inexpensive base like NaOH and a non-toxic alkylating agent such as methyl p-toluenesulfonate. The R enantiomer is isolated from the racemic mixture of lacosamide after selective hydrolysis of the acetamide, followed by salification with a chiral acid in an organic solvent. The resolution of the diastereoisomeric mixture is preferably achieved through the precipitation of the R enantiomer, culminating in the acetylation of the optically pure intermediate.
Another significant patent involves the synthesis of ritonavir. This process allows for the preparation of ritonavir with only five intermediate stages, utilizing the same starting materials as previous methods. This approach is particularly advantageous from an environmental perspective, as nearly all carbon atoms used are incorporated into the final molecule. The process is enhanced by the use of an inexpensive reagent, bis-trichloromethyl carbonate (BTC), in two of the five stages.
Career Highlights
Throughout her career, Patrizia has worked with prominent companies in the pharmaceutical industry, including Clariant Life Science Molecules and Euticals Spa. Her expertise in chemical processes has made her a valuable asset in these organizations.
Collaborations
Patrizia has collaborated with notable colleagues such as Pietro Bellani and Marco Frigerio. These partnerships have contributed to her innovative work and the successful development of her patented processes.
Conclusion
Patrizia Castoldi's contributions to pharmaceutical chemistry through her innovative patents demonstrate her commitment to advancing drug synthesis methods. Her work not only enhances the efficiency of drug production but also emphasizes environmental sustainability.