Patricia Raney

Title: The Innovations of Patricia Raney

Introduction

Patricia Raney is a notable inventor based in Somerville, MA (US). She has made significant contributions to the field of biotechnology, particularly in the area of protein production. Her work has led to advancements that enhance the efficiency of bacterial host cells in producing heterologous proteins.

Latest Patents

Patricia Raney holds a patent for "Bacterial hypersecretion using mutant repressor sequence." This invention provides an improved bacterial host cell that is useful for the inducible production and secretion of heterologous proteins in high yields. The patented technology involves a gene encoding the heterologous protein that is operatively linked to a secretory leader-encoding sequence and an expression control sequence containing a promoter region. Additionally, it includes a second DNA sequence encoding a repressor capable of binding to the promoter region. The cell features mutations in the repressor binding region of the promoter or the promoter binding region of the repressor-encoding sequence, which results in higher yields of secreted heterologous protein.

Career Highlights

Patricia has worked at Genetics Institute, Inc., where she has been able to apply her innovative ideas in a collaborative environment. Her work has been instrumental in advancing the capabilities of bacterial systems for protein production.

Collaborations

Throughout her career, Patricia has collaborated with notable colleagues such as Paul F. Schendel and Marc Nasoff. These collaborations have contributed to the success of her projects and the advancement of their shared goals in biotechnology.

Conclusion

Patricia Raney's contributions to the field of biotechnology through her innovative patent demonstrate her commitment to enhancing protein production methods. Her work continues to influence the industry and pave the way for future advancements.