Patricia Grom

Title: Patricia Grom: Innovator in Biological Sample Preparation

Introduction

Patricia Grom is a notable inventor based in Coral Springs, FL (US). She has made significant contributions to the field of biological sample preparation, particularly in the context of cytometric analysis of cell signaling pathways. Her innovative methods have the potential to enhance the understanding of disease-specific characteristics through the preservation of intracellular protein epitopes.

Latest Patents

Patricia Grom holds a patent for a method titled "Whole blood preparation for cytometric analysis of cell signaling pathways." This invention is directed to a method for the preparation of a biological sample for the measurement of protein epitopes. It allows for the preservation of intracellular protein epitopes and the detection of signal transduction pathways by capturing transient activation states of the epitopes. The method enables the rapid fixation of biological samples containing red blood cells, ensuring that the epitopes of signal transduction molecules remain in an active state. Additionally, it allows for the lysis of red blood cells, making it useful for cytometric analysis of various biological samples, including whole blood and bone marrow aspirates. The invention also provides a method to recover or 'unmask' epitopes on intracellular antigens that have been made inaccessible by the cross-linking fixative necessary for sample fixation. Importantly, these methods facilitate the preservation and analysis of phospho-epitope levels in biological samples taken directly from patients.

Career Highlights

Throughout her career, Patricia Grom has worked with esteemed organizations such as the University Health Network and Beckman Coulter, Inc. Her experience in these institutions has contributed to her expertise in the field of biological research and innovation.

Collaborations

Patricia has collaborated with notable colleagues, including Sue Chow and David Hedley. These partnerships have likely enriched her work and expanded the impact of her inventions.

Conclusion

Patricia Grom's innovative methods in biological sample preparation represent a significant advancement in the field of cytometric analysis. Her contributions have the potential to improve the understanding of disease mechanisms and enhance diagnostic capabilities.