Paola Bargagna-Mohan

Title: Paola Bargagna-Mohan: Innovator in Withanolide Research

Introduction

Paola Bargagna-Mohan is a prominent inventor based in Lexington, KY (US). She has made significant contributions to the field of chemical genetics, particularly through her research on withanolides. With a total of 2 patents, her work focuses on identifying binding targets and developing methods for drug screening.

Latest Patents

Bargagna-Mohan's latest patents include innovative methods for utilizing withanolides as chemical genetic probes. One of her notable patents describes how novel withanolide probes can identify the in vivo binding target of withaferin A, specifically the intermediate filament type III protein vimentin. This method involves introducing a tagged linker that is covalently bonded to the withanolide molecule, forming a withanolide probe. The probes can be used to monitor the expression of vimentin in tumor samples or other diseased tissues. Additionally, her research provides methods for screening drugs effective for treating fibrotic conditions, highlighting the potential of withanolide compounds as inhibitors of fibrosis.

Career Highlights

Bargagna-Mohan is affiliated with the University of Kentucky Research Foundation, where she continues her groundbreaking research. Her work has implications for treating various vimentin-associated disorders, including cancers and chronic inflammation.

Collaborations

Some of her notable collaborators include Royce Mohan and Kyung Bo Kim, who contribute to her research endeavors.

Conclusion

Paola Bargagna-Mohan's innovative research in withanolide compounds showcases her commitment to advancing medical science. Her patents reflect her dedication to developing effective treatments for fibrotic diseases and cancer-related disorders.