Pamela Wagner

Title: Innovations of Pamela Wagner in Transfection Technology

Introduction

Pamela Wagner is a notable inventor based in Vancouver, Canada. She has made significant contributions to the field of biotechnology, particularly in the development of transfection-competent vesicles. With a total of two patents to her name, her work focuses on enhancing the delivery of genetic materials into target cells.

Latest Patents

Wagner's latest patents include compositions and systems comprising transfection-competent vesicles that are free of organic solvents and detergents. These lipid-based vesicles, known as transfection competent vesicles (TCVs), are designed to safely and efficiently deliver DNA, RNA, and other nucleic acid and protein cargoes into target cells. The innovative aspect of her work lies in the elimination of harmful organic solvents, such as ethanol, and detergents, like sodium dodecyl sulfate, from the TCV loading, storage, and delivery processes. This advancement not only enhances safety but also improves the efficiency of the transfection process. Additionally, the cargoes can include nucleic acids complexed with proteins, such as ribonucleoproteins (RNPs). In some embodiments, her systems and methods can provide empty TCVs that can be loaded at the bench without the need for specialized equipment.

Career Highlights

Pamela Wagner is affiliated with the University of British Columbia, where she continues her research and development in the field of biotechnology. Her work has garnered attention for its potential applications in gene therapy and molecular biology.

Collaborations

Wagner collaborates with her coworker, Blair Leavitt, to further advance their research initiatives.

Conclusion

Pamela Wagner's innovative work in transfection technology represents a significant step forward in the safe and efficient delivery of genetic materials. Her contributions are poised to impact various fields, including medicine and biotechnology.