Company Filing History:
Years Active: 1995-1999
Title: The Innovative Contributions of Pamela S. Olson
Introduction
Pamela S. Olson is a prominent inventor based in Cupertino, California. She has made significant contributions to the field of biotechnology, particularly in the development of methods for producing recombinant proteins. With a total of six patents to her name, her work has had a substantial impact on the industry.
Latest Patents
One of her latest patents is titled "Expression of fusion polypeptides transported out of the cytoplasm." This invention focuses on using a fusion partner that lacks a leader sequence to enhance the solubility and activity of recombinant polypeptides. The method facilitates the expression of fusion proteins, which are subsequently transported out of the cytoplasm. The patent includes a nucleic acid encoding a fusion polypeptide that comprises a mature interleukin-1-like polypeptide or a leader-deleted-translocating polypeptide, along with a polypeptide of interest. It also encompasses host cells containing such nucleic acids and the methods for producing recombinant fusion polypeptides.
Another significant patent is "Chromosomal expression of heterologous genes in bacterial cells." This invention provides compositions and methods for producing a heterologous protein of interest by integrating a gene encoding the protein into the chromosome of a host cell, such as E. coli. The method utilizes a chromosomal transfer DNA that integrates the gene into the host cell chromosome, allowing for the expression of the protein of interest after integration.
Career Highlights
Pamela has worked with notable companies, including Celtrix Pharmaceuticals, Inc. Her experience in these organizations has contributed to her expertise in biotechnology and patent development.
Collaborations
Throughout her career, Pamela has collaborated with esteemed colleagues such as Desmond D. Mascarenhas and Yang Zhang. These partnerships have further enriched her work and innovations in the field.
Conclusion
Pamela S. Olson's contributions to biotechnology through her innovative patents and collaborations highlight her role as a leading inventor in her field. Her work continues to influence the development of recombinant proteins and related technologies.