Company Filing History:
Years Active: 2014-2017
Title: The Innovations of Pamela S. Fink
Introduction
Pamela S. Fink is a notable inventor based in New City, NY (US). She has made significant contributions to the field of biochemistry, particularly in the purification of capsular polysaccharides. With a total of 2 patents to her name, her work has implications for vaccine development and other medical applications.
Latest Patents
Fink's latest patents describe a shortened process for producing a solution containing substantially purified capsular polysaccharides from a cellular lysate broth. The process involves ultrafiltering and diafiltering a clarified lysate, followed by pH adjustment to less than 4.5, which precipitates at least 98% of the protein in the solution without significantly affecting polysaccharide yield. Additionally, after ultrafiltration and diafiltration, acidification to a pH of less than 4.5, and filtration using activated carbon, at least 90% of the remaining protein can be precipitated without seriously affecting polysaccharide yield. The exemplary serotypes that can be purified using this process include 1, 4, 5, 6A, 6B, 7F, 9V, 14, 18C, 19A, 19F, and 23F. In one embodiment, the cells are lysed using deoxycholate sodium (DOC), while in another, a non-animal derived lytic agent such as N-lauryl sarcosine sodium (NLS) is used.
Career Highlights
Pamela S. Fink has established herself as a key figure in her field through her innovative research and development efforts. She is currently associated with Wyeth, a company known for its contributions to pharmaceuticals and vaccines. Her work has not only advanced scientific understanding but has also paved the way for practical applications in medicine.
Collaborations
Fink has collaborated with notable colleagues such as Yonghui Yuan and Mark Edward Ruppen. These partnerships have further enhanced her research capabilities and have contributed to the success of her projects.
Conclusion
Pamela S. Fink's contributions to the field of biochemistry through her patents and collaborations highlight her role as an influential inventor. Her innovative processes for purifying capsular polysaccharides are significant advancements in medical research and development