P Leo McGrane

Title: The Innovative Genius of P Leo McGrane

Introduction

P Leo McGrane is a noteworthy inventor based in Mountain View, CA, who has made significant contributions to the field of drug delivery systems. With a portfolio of 7 patents, his work focuses on enhancing the efficacy of drug delivery across various epithelial and endothelial tissues, providing new avenues for therapeutic applications.

Latest Patents

Among McGrane's most recent inventions are two key patents aimed at improving drug delivery mechanisms. The first patent, "Compositions and methods for enhancing drug delivery across and into epithelial tissues," details innovative compositions that facilitate the delivery of drugs across various epithelial layers, including the skin, gastrointestinal tract, and ocular tissues. This technology utilizes a delivery-enhancing transporter with specific guanidino or amidino sidechain moieties to maximize the efficacy of compounds when conjugated with this reagent.

The second patent, "Compositions and methods for enhancing drug delivery across and into ocular tissues," focuses on improving drug delivery specifically to ocular tissues. Similar in mechanism to the previous invention, this development employs delivery-enhancing polymers, such as poly-arginine molecules, to effectively penetrate the ocular barriers and enhance therapeutic delivery.

Career Highlights

Throughout his career, McGrane has been associated with innovative companies that push the boundaries of therapeutic development. He has worked with Cellgate, Inc., where he contributed to advancements in cellular drug delivery mechanisms. Additionally, his tenure at Kai Pharmaceuticals, Inc. has further solidified his reputation as an impactful inventor in the pharmaceutical field.

Collaborations

P Leo McGrane's journey in innovation has also involved collaborations with prominent colleagues, including Jonathan B Rothbard and Paul A Wender. These partnerships have played a significant role in the development of his patents and furthered research in drug delivery technologies.

Conclusion

P Leo McGrane stands out as a visionary inventor whose work in enhancing drug delivery systems underscores the importance of innovation in medical technology. His patents reflect a commitment to addressing complex challenges in the pharmaceutical arena, paving the way for more effective treatments and better patient outcomes.