Osamu Shiho

Title: Osamu Shiho: Innovator in Neurotrophin Research

Introduction

Osamu Shiho is a prominent inventor based in Takashima-gun, Japan. He has made significant contributions to the field of neurobiology through his innovative research and patents. His work focuses on the development of embryonic stem cells and their applications in understanding sensory neuron development.

Latest Patents

Shiho holds a patent for "Neurotrophin-3-deficient embryonic stem cells and mice and their use." This invention provides mouse embryonic stem cells and homozygous mutant mice carrying disruptions in the neurotrophin-3 (NT-3) gene. The mutations result from homologous recombination, which leads to the insertion of a reporter gene or a drug-resistance gene into an exon of the NT-3 gene. The mice with these homozygous mutations exhibit a reduced number of sensory neurons compared to mice without such mutations. These mice can be utilized to screen for substances that enhance the transcriptional activity of the NT-3 gene.

Career Highlights

Osamu Shiho is associated with Takeda Chemical Industries, Inc., where he continues to advance his research in neurobiology. His work has implications for understanding sensory neuron development and potential therapeutic applications.

Collaborations

Shiho has collaborated with notable colleagues, including Yoshihiko Kaisho and Hideaki Tojo. Their combined expertise contributes to the advancement of research in the field.

Conclusion

Osamu Shiho's innovative work in neurotrophin research and his patent on NT-3-deficient embryonic stem cells highlight his contributions to science. His research has the potential to impact the understanding of sensory neuron development and therapeutic strategies.