Oren Ram

Title: **Innovator Spotlight: Oren Ram from Chestnut Hill, MA**

Introduction

Oren Ram is an accomplished inventor based in Chestnut Hill, Massachusetts, recognized for his contributions to the field of epigenetics and microfluidics. With a solid foundation in innovative research, he has successfully been granted two patents that showcase his expertise and groundbreaking work in these areas.

Latest Patents

Oren's latest patents focus on systems and methods for epigenetic sequencing. This invention relates to the use of microfluidics for analyzing DNA obtained from cells encapsulated in microfluidic droplets. The process involves lysing the cells to label their DNA, particularly from nucleosomes, with adapters containing identification sequences and other useful domains, such as restriction and primer sites. After labeling, the DNA can be mixed and analyzed, allowing for the determination of epigenetic characteristics of the cells. One notable aspect of this invention is the ability to separate DNA based on specific modifications, such as methylation, and to sequence the components using techniques like chromatin immunoprecipitation (ChIP). Furthermore, the DNA sequences can be aligned with reference genomes to reveal epigenetic modifications across various genomic regions.

Career Highlights

Oren Ram has built a remarkable career that reflects his dedication to advancing scientific knowledge. He has served in notable positions at leading research institutions, including The General Hospital Corporation and Harvard College. His work at these organizations has had a significant impact on the medical and scientific communities, particularly in the areas of genetics and molecular biology.

Collaborations

Throughout his career, Oren has worked alongside distinguished colleagues, including Assaf Rotem and Bradley Bernstein. These collaborations have further enhanced his research efforts and contributed to the development of innovative technologies in the realm of epigenetics.

Conclusion

Oren Ram stands out as a pioneer in the field of epigenetics, particularly through his innovative approaches to microfluidics. His patents not only underscore his inventive spirit but also highlight the potential for significant advancements in understanding epigenetic modifications. As he continues to push the boundaries of scientific research, Oren's contributions are sure to influence both current and future studies in genetics.