Company Filing History:
1 out of 832,718 Years Active: 1999
Title: The Innovative Contributions of Norman M Greenberg
Introduction
Norman M Greenberg is a notable inventor based in Houston, TX (US). He has made significant contributions to the field of cancer research, particularly in the development of transgenic mouse models for studying prostate cancer. His work has implications for understanding the molecular mechanisms underlying this prevalent disease.
Latest Patents
Norman M Greenberg holds 1 patent for his invention titled "Transgenic mouse model for prostate cancer." This patent describes the generation of several lines of transgenic mice that utilize the prostate-specific rat probasin (PB) gene promoter to drive the expression of the SV40 T antigen (Tag) coding region. The mice that express high levels of the transgene exhibit progressive forms of prostatic cancer that closely resemble human prostate cancer, ranging from mild prostatic intraepithelial neoplasia (PIN) to large multinodular malignant adenocarcinoma with metastasis. Notably, adenocarcinomas of the prostate have been detected as early as 10 weeks of age, with evidence of extracapsular extension (ECE) and seminal vesicle invasion (SVI).
Career Highlights
Throughout his career, Greenberg has focused on creating animal models that can effectively mimic human diseases. His innovative approach has provided researchers with valuable tools to study the progression of prostate cancer and the factors that influence its development. The establishment of breeding lines of transgenic mice that reproducibly develop prostate cancer with metastasis offers a unique opportunity to investigate the molecular basis of transformation in normal prostatic cells.
Collaborations
Some of Norman M Greenberg's notable collaborators include Robert J Matusik and Jeffrey M Rosen. Their combined expertise has contributed to advancing research in the field of prostate cancer.
Conclusion
Norman M Greenberg's work in developing transgenic mouse models has significantly enhanced our understanding of prostate cancer. His innovative contributions continue to pave the way for future research and potential therapeutic strategies.
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