Norman M Fedalizo

Title: The Innovations of Norman M. Fedalizo

Introduction

Norman M. Fedalizo is a notable inventor based in Rowland Heights, California. He has made significant contributions to the field of biopharmaceuticals, particularly in the purification and viral inactivation of blood proteins. With a total of 2 patents, his work has had a meaningful impact on medical treatments involving Factor VIII.

Latest Patents

One of his latest patents is titled "Process for Viral Inactivation of Lyophilized Blood Proteins." This innovative process involves forming a stable complex between Factor VIII and a cyclodextrin in an aqueous solution. The solution is then lyophilized, and the Factor VIII/cyclodextrin complex is recovered. The lyophilized product is subsequently heated to 60°C to inactivate any viral contaminants, ensuring safety for patient administration.

Another significant patent is the "Anion Exchange Process for the Purification of Factor VIII." This method provides a new approach for purifying the Factor VIII complex from impure protein fractions, typically cryoprecipitate. The cryoprecipitate is dissolved in a heparin solution, and the Factor VIII complex is initially purified through polyethylene glycol precipitation. The resulting supernatant is then processed through an anion exchange column, leading to a highly purified Factor VIII product.

Career Highlights

Norman M. Fedalizo has been associated with Alpha Therapeutic Corporation, where he has contributed to advancements in blood protein purification and safety. His innovative approaches have positioned him as a key figure in the biopharmaceutical industry.

Collaborations

Throughout his career, Norman has collaborated with esteemed colleagues such as Prabir Bhattacharya and Toshiharu Motokubota. These partnerships have fostered a collaborative environment that enhances research and development efforts.

Conclusion

Norman M. Fedalizo's contributions to the field of biopharmaceuticals through his patents and collaborations highlight his dedication to improving medical treatments. His innovative processes for viral inactivation and purification of Factor VIII continue to influence the industry positively.