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Years Active: 2025
Title: Norio Chihara: Innovator in Immunotherapy
Introduction
Norio Chihara is a prominent inventor based in Boston, MA, known for his significant contributions to the field of immunotherapy. With a total of two patents, he has made strides in understanding and modulating immune checkpoint targets, particularly in the context of chronic diseases such as cancer.
Latest Patents
Chihara's latest patents focus on the modulation of novel immune checkpoint targets. Dysfunctional or exhausted T cells, which arise in chronic diseases including chronic viral infections and cancer, express high levels of co-inhibitory receptors. Therapeutic blockade of these receptors has shown clinical efficacy in cancer treatment. His research identifies the immunoregulatory cytokine IL-27, which induces a gene module in T cells that includes several known co-inhibitory receptors such as Tim-3, Lag-3, and TIGIT. The inventions provide a novel immunoregulatory network and cell surface molecules that have an inhibitory function in the tumor microenvironment. Furthermore, Chihara discovered that the transcription factors Prdm1 and c-Maf cooperatively regulate the expression of the co-inhibitory receptor module, which is crucial for understanding T cell dysfunction.
Career Highlights
Throughout his career, Norio Chihara has worked with esteemed institutions, including Brigham and Women's Hospital and the Broad Institute. His work has significantly advanced the understanding of immune responses and therapeutic strategies in oncology.
Collaborations
Chihara has collaborated with notable professionals in his field, including Ana Carrizosa Anderson and Asaf Madi. These collaborations have further enriched his research and contributions to immunotherapy.
Conclusion
Norio Chihara's innovative work in immunotherapy and his patents on immune checkpoint modulation highlight his role as a key figure in advancing cancer treatment. His research continues to pave the way for new therapeutic strategies in the fight against chronic diseases.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.