Location History:
- Kanagawa-ken, JP (2002)
- Kawasaki, JP (1988 - 2006)
- Tokyo, JP (2010 - 2012)
- Kanagawa, JP (2004 - 2013)
Company Filing History:
Years Active: 1988-2013
Title: Innovations of Norimasa Onishi: Advancements in Amino Acid Production
Introduction
Norimasa Onishi, based in Kanagawa, Japan, is a prolific inventor with an impressive portfolio of 19 patents. His work primarily focuses on biotechnological advancements related to amino acids, showcasing innovative methodologies for producing optically active amino acids and microbial transglutaminase.
Latest Patents
Onishi's latest patents include significant innovations such as:
- **DNA encoding hydantoinase**
- **DNA encoding N-carbamyl-L-amino acid hydrolase**
- **Recombinant DNA, transformed cell, method of producing protein**
- **Method of producing optically active amino acids**
The method for producing optically active amino acids involves isolating both a hydantoinase gene and an N-carbamyl-L-amino acid hydrolase gene from microorganisms. By advancing gene amplification and enhancing transcriptional and translational activities, Onishi's work enables a higher yield of desired enzymes. Notably, the hydantoinase gene corresponds to a DNA sequence that exhibits hydantoinase activity, specifically the nucleotide sequence of SEQ ID NO:1, while the N-carbamyl-L-amino acid hydrolase gene aligns with the sequence of SEQ ID NO:3.
Additionally, his innovation in the **method of producing microbial transglutaminase** describes a neutral metalloprotease derived from actinomycetes, which selectively cleaves the pro-structure part of microbial protransglutaminase. This breakthrough allows for the production of active microbial transglutaminase, enhancing its application in various biotechnological processes.
Career Highlights
Norimasa Onishi is currently affiliated with Ajinomoto Co., Ltd., a leading global food and biotechnology company. His contributions to the field of biotechnology, particularly in amino acid production, have positioned him as a key innovator within the industry.
Collaborations
Throughout his career, Onishi has collaborated with notable colleagues such as Kenzo Yokozeki and Shunichi Suzuki. Their joint efforts have significantly advanced research in bioprocessing and protein production techniques.
Conclusion
Norimasa Onishi's innovative work in the realm of biotechnology has established him as a significant contributor to the field. His 19 patents reflect a commitment to advancing methodologies that enhance the efficiency of amino acid production and provide valuable solutions for biotechnological applications. The collaborations with esteemed colleagues further amplify the impact of his research within the scientific community.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.