Norbert Perrimon

Title: Norbert Perrimon: Innovator in RNA Technology

Introduction

Norbert Perrimon is a distinguished inventor based in Brookline, MA (US). He has made significant contributions to the field of molecular biology, particularly in the development of innovative ribozymes. With a total of 7 patents, his work has paved the way for advancements in RNA technology.

Latest Patents

One of Perrimon's latest patents focuses on cell ablation using trans-splicing ribozymes. This patent describes the design of new ribozymes capable of self-catalyzed trans-splicing, based on the catalytic core of a Group I intron. Using this design, it is possible to construct ribozymes that can efficiently splice a new 3' exon sequence into any chosen target RNA sequence with high precision. Additionally, the patent outlines a method of cell ablation that provides a toxic product to a host cell in vivo in a targeted and regulated manner, utilizing the novel trans-splicing ribozymes he invented. Inactive pro-ribozyme forms are also described in this patent.

Career Highlights

Throughout his career, Norbert Perrimon has worked with notable institutions, including The General Hospital Corporation and Harvard College. His research has significantly impacted the understanding of RNA biology and its applications in therapeutic contexts.

Collaborations

Perrimon has collaborated with esteemed colleagues such as James Haseloff and Andrea Brand, contributing to a rich exchange of ideas and advancements in their respective fields.

Conclusion

Norbert Perrimon's innovative work in RNA technology and his numerous patents highlight his role as a leading inventor in molecular biology. His contributions continue to influence research and applications in the field.