Norbert Engel

Title: Norbert Engel: Innovator in Pharmaceutical Chemistry

Introduction

Norbert Engel is a notable inventor based in Bonn, Germany. He has made significant contributions to the field of pharmaceutical chemistry, particularly through his innovative patent work. His research focuses on valuable intermediates for drug synthesis, which can have a profound impact on medical treatments.

Latest Patents

Engel holds a patent for 2-(O-Hydroxyphenyl)-pyrrole and the process for its preparation. This patent describes a method where o-benzyloxybenzoic acid allylamide is reacted with phosgene in an inert solvent. The resulting imide-chloride is cyclized in the presence of a strong sterically hindered base, followed by the removal of the benzyl protective group through hydrogenolysis. The compound 2-(o-Hydroxyphenyl)-pyrrole serves as a valuable intermediate for drug synthesis. Specifically, alkylamino-hydroxypropyl ethers derived from this compound can be utilized for treating coronary cardiac diseases, cardiac arrhythmias, and hypertonia due to their β-sympatholytic actions.

Career Highlights

Norbert Engel is associated with BASF Aktiengesellschaft, a leading chemical company known for its innovative solutions in various industries. His work at BASF has allowed him to contribute to advancements in pharmaceutical chemistry, enhancing the development of new therapeutic agents.

Collaborations

Engel has collaborated with notable colleagues such as Horst Koenig and Albrecht Franke. These partnerships have fostered a collaborative environment that encourages innovation and the sharing of ideas in the field of chemistry.

Conclusion

Norbert Engel's contributions to pharmaceutical chemistry through his patent for 2-(O-Hydroxyphenyl)-pyrrole highlight his role as an influential inventor. His work not only advances scientific knowledge but also has the potential to improve medical treatments for various conditions.