Company Filing History:
Years Active: 1990-1993
Title: The Innovations of Nolan H Sigal
Introduction
Nolan H Sigal is a notable inventor based in Westfield, NJ (US). He has made significant contributions to the field of immunology through his innovative research and development of binding proteins. With a total of 3 patents to his name, Sigal's work has had a profound impact on the medical and pharmaceutical industries.
Latest Patents
One of Sigal's latest patents is the development of a new homogeneous cytosolic binding (HCB) protein. This protein exhibits a specific binding activity of about 26 µg FK-506 per mg protein and has a molecular weight of approximately 10-12 kilodaltons. It reversibly binds the immunosuppressant FK-506 but not cyclosporine A (CSA). Remarkably, the protein remains stable when heated at 56 degrees Celsius for 30 minutes, retaining its FK-506 binding affinity. The HCB protein has a partial amino terminal amino acid sequence that includes various amino acids and is isolated from the cytosol of mammalian tissues, preferably human neoplastic T-cell lines such as Jurkat. This protein can be utilized in diagnostic and purification procedures involving FK-506 macrolide type immunosuppressants. Additionally, the HCB protein catalyzes the cis-trans isomerization of proline-containing peptide bonds.
Career Highlights
Nolan H Sigal is currently associated with Merck & Company, Inc., where he continues to advance his research in the field of immunology. His work has been instrumental in developing new therapeutic approaches and enhancing the understanding of immunosuppressant mechanisms.
Collaborations
Throughout his career, Sigal has collaborated with esteemed colleagues, including John J Siekierka and Hsuen-Yun Hung. These collaborations have further enriched his research and contributed to the success of his innovative projects.
Conclusion
Nolan H Sigal's contributions to the field of immunology through his patents and research have established him as a prominent inventor. His work continues to influence the development of new therapeutic strategies in the medical field.