Company Filing History:
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Years Active: 2016-2021
Title: Ning Zheng: Innovator in Protein Expression and Degradation Technologies
Introduction
Ning Zheng is a prominent inventor based in Shoreline, WA (US), known for his contributions to the field of protein expression and degradation. With a total of 2 patents, he has made significant strides in developing innovative systems that enhance protein regulation in mammalian cells.
Latest Patents
One of his latest patents is titled "System for F-box hormone receptor regulated protein expression in mammalian cells." This invention relates to a system that includes a silencing nucleic acid molecule with a first promoter and an shRNA operably linked to it, which silences the expression of a target protein. Additionally, it features an expression nucleic acid molecule with a second promoter, an F-box hormone receptor, and a nucleic acid molecule encoding a fusion protein that includes a degron fused to the target protein. The patent also discloses vectors comprising this system and methods for its use.
Another significant patent is "Methods and compositions for targeted protein degradation." This invention highlights the role of coronatine in enhancing the binding of the JAZ1 degron to the F-box protein COI1. The analysis of the JAZ1 degron sequence has led to the identification of specific peptide sequences that bind COI1 with high affinity in the presence of coronatine. The patent provides compositions, methods, and kits for targeted protein degradation, showcasing the innovative approaches Zheng has developed in this area.
Career Highlights
Ning Zheng has worked with esteemed institutions such as the University of Washington and the Icahn School of Medicine at Mount Sinai. His work in these organizations has allowed him to collaborate with leading researchers and contribute to groundbreaking advancements in his field.
Collaborations
Some of his notable coworkers include Ran Brosh, Sr and Ihor R Lemischka. Their collaborative efforts have further enriched the research environment and fostered innovation in protein expression and degradation technologies.
Conclusion
Ning Zheng's contributions to the field of protein expression and degradation are noteworthy, with his innovative patents paving the way for advancements in biotechnology. His work continues to influence research and development in this critical area of science.