Nigel Killeen

Title: The Innovations of Nigel Killeen

Introduction

Nigel Killeen is a notable inventor based in Hillsborough, California. He has made significant contributions to the field of biotechnology, particularly in the development of engineered human IL-21 cytokines. His work has implications for various medical treatments and advancements.

Latest Patents

Killeen holds a patent for "Engineered human IL-21 cytokines and methods for using the same." This patent describes orthogonal IL-21 receptors and orthogonal IL-21 cytokines. The IL-21 receptor-cytokine pairs include an orthogonal interleukin-21 receptor α chain, known as 'ortho-IL-21Rα', which has impaired binding to native interleukin-21 cytokine. Additionally, the orthogonal IL-21 cytokine, referred to as “ortho-IL-21”, has impaired binding to native IL-21Rα. The ortho-IL-21Rα binds specifically to the ortho-IL-21, allowing for the activation of IL-21 signaling. Killeen's patent also describes cells engineered to express these orthogonal IL-21 receptors, along with methods for using such cells in the treatment of various diseases and disorders.

Career Highlights

Killeen's career is marked by his innovative research and development in cytokine engineering. His work has paved the way for new therapeutic approaches in treating diseases that involve the immune system. His expertise in this area has made him a valuable asset in the biotechnology sector.

Collaborations

Killeen has collaborated with notable colleagues, including Oren Beske and Benedikt K Vollrath. These partnerships have further enhanced his research and contributed to the advancement of his patented technologies.

Conclusion

Nigel Killeen's contributions to the field of biotechnology through his innovative patents and collaborations highlight his role as a leading inventor. His work continues to influence the development of new treatments for various medical conditions.