This inventor holds 3 USPTO granted patents. Top assignees: Institut Pasteur, Other. Active years: 1994-1995.
Location History:
- Strasbourg, FR (1994)
- 67085 Strasbourg, FR (1995)
Company Filing History:
2 out of 897 
1 out of 834,307 Years Active: 1994-1995
Title: The Innovative Contributions of Nigel Brand
Introduction
Nigel Brand is a notable inventor based in Strasbourg, France. He has made significant contributions to the field of molecular biology, particularly in the study of hepatitis B virus and its implications in hepatocellular carcinoma. With a total of 3 patents to his name, Brand's work has advanced our understanding of gene expression and receptor biology.
Latest Patents
One of Nigel Brand's latest patents involves a steroid/thyroid hormone receptor-related gene. This research utilized a previously isolated hepatitis B virus (HBV) integration in a 147 bp cellular DNA fragment linked to hepatocellular carcinoma (HCC) as a probe to clone the corresponding complementary DNA from a human liver cDNA library. Nucleotide sequence analysis revealed that the overall structure of the cellular gene, named hap, is similar to that of DNA-binding hormone receptors. Notably, six out of seven hepatoma and hepatoma-derived cell lines express a 2.5 kb hap mRNA species, which is undetectable in normal adult and fetal livers but present in all non-hepatic tissues analyzed. Low stringency hybridization experiments indicated the existence of hap-related genes in the human genome. The cloned DNA sequence is useful for preparing pure hap protein and serves as a probe in the detection and isolation of complementary DNA and RNA sequences. The hap protein is identified as a retinoic acid (RA) receptor known as RAR-.beta., which is transcriptionally up-regulated by retinoic acid and may contain a retinoic acid responsive element in its promoter region.
Career Highlights
Throughout his career, Nigel Brand has worked with prestigious institutions, including the Institut Pasteur. His research has contributed to the understanding of molecular mechanisms underlying various diseases, particularly those related to liver cancer.
Collaborations
Some of his notable coworkers include Agnes Marchio and Pierre Tiollais. Their collaborative efforts have furthered the research in the field of molecular biology and genetics.
Conclusion
Nigel Brand's innovative work and patents have significantly impacted the field of molecular biology, particularly in understanding the relationship between hepatitis B virus and liver cancer. His contributions continue to influence ongoing research and development in this critical area of health science.