Nicole Schiavone

Title: Innovations in Mass Spectrometry: The Contributions of Nicole Schiavone

Introduction

Nicole Schiavone is an accomplished inventor based in South Bend, Indiana. She has made significant contributions to the field of mass spectrometry, particularly through her innovative patent that enhances the efficiency of electrospray mass spectrometry.

Latest Patents

Nicole Schiavone holds a patent for an electrokinetically pumped sheath flow nanospray interface for capillary electrophoresis coupled to a negative mode electrospray mass spectrometer. This invention describes a method where the application of an electric field generates electro-osmotic flow within a glass emitter. The electroosmotic flow effectively pumps liquid around the distal tip of the separation capillary, ensheathing analyte into the electrospray electrolyte. In negative ion mode, the negative potential applied to an untreated emitter drives sheath flow away from the emitter orifice, which can decrease the stability and efficiency of the spray. However, by grafting the interior of the electrospray emitter with aminoalkylsilanes, the positive charge of the amines reverses electroosmosis, generating stable sheath flow under negative potential. The limits of detection for this method were found to be approximately 150 to 900 attomoles injected, and its effectiveness was demonstrated by analyzing a metabolite extract from stage 1 embryos.

Career Highlights

Nicole Schiavone is affiliated with the University of Notre Dame, where she continues to advance her research in mass spectrometry. Her work has garnered attention for its innovative approach to improving detection limits and efficiency in analytical chemistry.

Collaborations

Nicole has collaborated with notable colleagues in her field, including Norman Dovichi and Scott Sarver. Their combined expertise has contributed to the advancement of research in mass spectrometry and related technologies.

Conclusion

Nicole Schiavone's contributions to the field of mass spectrometry through her innovative patent demonstrate her commitment to advancing scientific research. Her work not only enhances the efficiency of mass spectrometry but also paves the way for future innovations in analytical chemistry.