Nicole Maloof

Title: Nicole Maloof: Innovator in Sonic Hedgehog Modulation

Introduction

Nicole Maloof is a prominent inventor based in Brookline, MA (US). She has made significant contributions to the field of biomedical research, particularly in the modulation of the Sonic Hedgehog signaling pathway. Her work has implications for treating various proliferative diseases and developmental disorders.

Latest Patents

Nicole Maloof holds a patent related to Sonic hedgehog modulators. The present invention pertains to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, along with their syntheses and intermediates. These small molecule modulators are valuable in treating proliferative diseases such as basal cell carcinoma, Gorlin syndrome, medulloblastoma, and pancreatic cancer. They also have applications in pulmonary diseases like interstitial pneumonitis and interstitial pulmonary fibrosis, as well as developmental disorders such as phocomelia and cyclopia. The invention provides novel non-natural macrocycles that inhibit Sonic Hedgehog induced-protein transcription.

Career Highlights

Throughout her career, Nicole has worked with prestigious institutions, including Harvard College and the Massachusetts Institute of Technology. Her research has been instrumental in advancing the understanding of the Sonic Hedgehog pathway and its role in various diseases.

Collaborations

Nicole has collaborated with notable colleagues, including Lee F Peng and Julia Lamenzo. Their combined expertise has contributed to the success of her research endeavors.

Conclusion

Nicole Maloof is a trailblazer in the field of Sonic Hedgehog modulation, with a patent that holds promise for treating serious health conditions. Her work exemplifies the impact of innovative research on medical science and patient care.