The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 10, 2013
Filed:
Apr. 21, 2009
Lee F. Peng, Somerville, MA (US);
Julia Lamenzo, Arlington, MA (US);
Nicole Maloof, Brookline, MA (US);
Kazuo Nakai, Itami, JP;
Benjamin Stanton, Menlo Park, CA (US);
Sara Jean Buhrlage, Somerville, MA (US);
Lawrence Macpherson, Marlborough, MA (US);
Michel Weiwer, Cambridge, MA (US);
Stuart L. Schreiber, Boston, MA (US);
Lee F. Peng, Somerville, MA (US);
Julia Lamenzo, Arlington, MA (US);
Nicole Maloof, Brookline, MA (US);
Kazuo Nakai, Itami, JP;
Benjamin Stanton, Menlo Park, CA (US);
Sara Jean Buhrlage, Somerville, MA (US);
Lawrence MacPherson, Marlborough, MA (US);
Michel Weiwer, Cambridge, MA (US);
Stuart L. Schreiber, Boston, MA (US);
President and Fellows of Harvard College, Cambridge, MA (US);
Massachusetts Institute of Technology, Cambridge, MA (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
The present invention relates to macrocyclic small molecule inhibitors of the Sonic Hedgehog signaling pathway, syntheses thereof, and intermediates thereto. Such small molecule modulators of the Sonic Hedgehog signaling pathway are useful in the treatment of proliferative diseases (e.g., basal cell carcinoma, Gorlin syndrome, medulloblastoma, or pancreatic cancer), pulmonary diseases (e.g., interstitial pnuemonitis or interstitial pulmonary fibrosis), and developmental disorders (e.g., phocomelia or cyclopia). Novel non-natural macrocycles are provided that inhibit Sonic Hedgehog induced-protein transcription.