Company Filing History:
5 out of 106 
1 out of 106 
Years Active: 2018-2024
Title: Nicolas Wein: Innovator in Genetic Research
Introduction
Nicolas Wein is a prominent inventor based in Columbus, OH (US), known for his significant contributions to genetic research. He holds a total of 5 patents that focus on innovative methods for treating muscular dystrophies. His work has the potential to impact the lives of many individuals affected by these conditions.
Latest Patents
One of his latest patents is titled "Recombinant virus products and methods for inducing DUX4 exon skipping." This invention relates to methods for shifting the splicing profile of the DUX4 gene, which is a double homeobox gene located on human chromosome 4q35. The recombinant adeno-associated viruses developed in this patent deliver DNAs encoding U7-based small nuclear RNAs to induce DUX4 exon-skipping and promote the expression of shortened forms of DUX4. This method has applications in treating muscular dystrophies, particularly facioscapulohumeral muscular dystrophy.
Another notable patent is "Recombinant adeno-associated virus delivery of exon 2-targeted U7SNRNA polynucleotide constructs." This invention focuses on the rAAV delivery of polynucleotides aimed at treating Duchenne Muscular Dystrophy, which results from the duplication of DMD exon 2. The patent provides rAAV products and outlines methods for using these products in the treatment of Duchenne Muscular Dystrophy.
Career Highlights
Nicolas Wein has worked at esteemed institutions such as the Research Institute at Nationwide Children's Hospital and The University of Western Australia. His research has been pivotal in advancing the understanding and treatment of genetic disorders.
Collaborations
Throughout his career, Nicolas has collaborated with notable professionals in the field, including Kevin Flanigan and Adeline Vulin-Chaffiol. These collaborations have further enriched his research and contributed to the development of innovative solutions in genetic therapy.
Conclusion
Nicolas Wein's work exemplifies the intersection of innovation and medical research, particularly in the field of genetic disorders. His patents and collaborations highlight his commitment to improving treatment options for muscular dystrophies. His contributions continue to pave the way for advancements in genetic therapies.