Company Filing History:
Years Active: 1995
Title: Innovations of Nicholas Sisti
Introduction
Nicholas Sisti is a notable inventor based in Jeffersonville, PA (US). He has made significant contributions to the field of chemistry, particularly in the synthesis of camptothecin analogues. With a total of 2 patents to his name, Sisti's work showcases his expertise and dedication to innovation.
Latest Patents
One of Sisti's latest patents is a process for the asymmetric total synthesis of camptothecin analogues. This invention provides a method for the asymmetric synthesis of camptothecin analogs, along with novel chemical intermediates of Formula I, II, and III. The process involves the conversion of a cis dioxolanone, which has the same desired absolute configuration as the camptothecin analog, into a compound of Formula I, II, or III. This compound is then transformed into the desired camptothecin analog.
Career Highlights
Nicholas Sisti is currently associated with SmithKline Beecham Corporation, where he continues to advance his research and development efforts. His work has been instrumental in the field of medicinal chemistry, particularly in the development of cancer therapeutics.
Collaborations
Sisti has collaborated with notable colleagues such as Joseph Marian Fortunak and John Kitteringham. These collaborations have further enriched his research and contributed to the success of his innovative projects.
Conclusion
Nicholas Sisti's contributions to the field of chemistry, particularly through his patents and collaborations, highlight his role as a significant inventor. His work in the synthesis of camptothecin analogues demonstrates the impact of innovation in the development of new therapeutic agents.