This inventor holds 1 USPTO granted patent. Top assignees: Agency for Science, Technology and Research, National University of Singapore. Active years: 2025.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile
Company Filing History:
1 out of 1,562 
1 out of 857 
Years Active: 2025
Title: Innovations of Nicholas Rui Yuan Ho in Nucleic Acid Detection
Introduction
Nicholas Rui Yuan Ho is a notable inventor based in Singapore, recognized for his contributions to the field of nucleic acid detection. His innovative approach utilizes enzyme-assisted nanotechnology to enhance the specificity and sensitivity of nucleic acid detection methods. With a focus on integrating advanced technologies, he has made significant strides in this area.
Latest Patents
Nicholas Rui Yuan Ho holds a patent for his invention titled "Visual and modular detection of nucleic acids with enzyme-assisted nanotechnology." This invention provides methods and devices for the specific detection of nucleic acids using an integrated circuit of two independent enzyme-DNA nanostructures. The design features an easily adjustable recognition element and a sensitive universal signaling element, allowing for the decoupling of target recognition and visual signal amplification. The recognition element includes a DNA polymerase enzyme, a DNA polymerase enzyme-specific DNA aptamer, and an inverter oligonucleotide. When a target nucleic acid is present, the inverter oligonucleotide binds to it, releasing the DNA polymerase enzyme from inhibition by the DNA aptamer. The activated DNA polymerase enzyme then interacts with a signaling nanostructure, leading to the addition of labeled dNTPs and the binding of signal development reagents.
Career Highlights
Throughout his career, Nicholas Rui Yuan Ho has worked with prestigious institutions, including the National University of Singapore and the Agency for Science, Technology and Research. His work has significantly impacted the field of biotechnology, particularly in the development of innovative detection methods.
Collaborations
Nicholas has collaborated with various professionals in his field, including his coworker Huilin Shao. Their joint efforts have contributed to advancements in nucleic acid detection technologies.
Conclusion
Nicholas Rui Yuan Ho's innovative work in nucleic acid detection exemplifies the potential of enzyme-assisted nanotechnology in enhancing diagnostic methods. His contributions continue to influence the field and pave the way for future advancements.
Data source: USPTO (United States Patent and Trademark Office) public patent records. Weekly synchronization. How IDiyas builds this profile