Company Filing History:
Years Active: 2006-2013
Title: Innovations of Nicholas Callamaras in Olfactory Research
Introduction
Nicholas Callamaras is an accomplished inventor based in San Diego, CA. He has made significant contributions to the field of olfactory research, particularly through his innovative patents. With a total of 2 patents, Callamaras has focused on enhancing our understanding of the human olfactory system.
Latest Patents
His latest patents include the expression of functional human olfactory cyclic nucleotide gated (CNG) channel in recombinant host cells and the use thereof in cell-based assays to identify smell modulators. This invention relates to isolated nucleic acid sequences that encode human olfactory CNG channel subunits and the corresponding polypeptides. The invention further explores the use of human CNG channels to profile, screen for, and identify compounds that modulate the human olfactory CNG channel. More specifically, it discusses the expression of the human olfactory CNG channel in cells, preferably mammalian cells, and the use of these cells in high-throughput cell-based assays to identify compounds that enhance or block human olfactory CNG function. Compounds that activate the olfactory CNG channel will enhance smell and can be used to make foods more palatable for individuals with attenuated olfactory function. Conversely, compounds that inhibit the olfactory CNG channel will inhibit smell and can be used to block malodors. Additionally, the invention relates to the use of cell-based olfactory CNG channel assays to identify modulators of G-protein coupled receptors (GPCRs) and other proteins that regulate cyclic nucleotide levels.
Career Highlights
Nicholas Callamaras is currently associated with Senomyx, Inc., where he continues to advance his research in olfactory science. His work has the potential to impact various industries, including food and fragrance, by improving the understanding of how smell can be modulated.
Collaborations
Some of his notable coworkers include Mark Zoller and Hong Xu, who have collaborated with him on various projects within the field.
Conclusion
Nicholas Callamaras is a pioneering inventor whose work in olfactory research is paving the way for new innovations in the understanding and modulation of human smell. His contributions are significant and hold promise for future applications in enhancing sensory experiences.
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