Company Filing History:
Years Active: 2011-2014
Title: Innovations by Inventor Nicholas Cairns
Introduction
Nicholas Cairns is an accomplished inventor based in Los Altos, California. He has made significant contributions to the field of pharmaceuticals and biochemistry, holding a total of 3 patents. His work focuses on developing compounds and compositions that address various health issues, particularly those related to lipid levels and fluorescent dyes.
Latest Patents
Cairns' latest patents include innovative compounds and compositions aimed at reducing lipid levels. These compositions comprise extracts or isolated compounds from plants that provide prevention and treatment for conditions such as hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, hepatic steatosis, and metabolic syndrome. The compounds and their derivatives, both natural and synthetic, are designed to lower total cholesterol, LDL-cholesterol, and triglycerides while increasing hepatic LDL receptor expression and activating AMP-activated protein kinase. Specific stereoisomers of compounds with lipid-lowering activity include 14R-(+)-corypalmine, 14R,13S-(+)-corydaline, 14R-(+)-tetrahydropalmatin, (+)-corlumidin, d-(+)-bicuculline, and (+)-egenine.
Another notable patent involves sulfonyl cyanine dyes and derivatives. These fluorescent cyanine and squaraine dyes can be conjugated to analyte molecules of interest, such as peptides, proteins, nucleic acids, RNA, DNA, carbohydrates, polymers, and small molecules via a sulfonyl or sulfonamide substituent. The new dyes are produced through a novel activation procedure that transforms stable, water-solubilizing sulfonate substituents into reactive sulfonyl halides. These halides can be directly conjugated to analytes or converted into more stable reactive sulfonamide handles.
Career Highlights
Throughout his career, Nicholas Cairns has worked with various companies, including Cvi Pharmaceuticals Limited and Combinix, Inc. His expertise in the field has allowed him to contribute to significant advancements in pharmaceutical research and development.
Collaborations
Cairns has collaborated with notable professionals in his field, including Haiyan Liu and Junbo Wang. These partnerships have further enhanced his research and innovation efforts.
Conclusion
Nicholas Cairns is a prominent inventor whose work in developing compounds for