Company Filing History:
Years Active: 1976-1993
Title: Newton L Abramson: Innovator in Chemical Processes
Introduction
Newton L Abramson is a notable inventor based in Edison, NJ (US). He has made significant contributions to the field of chemistry, particularly in the development of novel chemical processes. With a total of 6 patents to his name, Abramson's work has had a considerable impact on various applications in the pharmaceutical industry.
Latest Patents
Among his latest patents, Abramson has developed a trialkylsilyl trifluoromethanesulfonate mediated process that produces derivatives of 4-aza 3-keto steroids at the .alpha.-methylenic carbon through electrophilic substitution. These derivatives are particularly useful in the preparation of .DELTA.-1 olefin 4-aza 3-keto steroids, which are known to be potent inhibitors of 5-.alpha. reductase. Additionally, he has created a novel and specific process for .alpha.-iodinating or .alpha.-brominating the .alpha.-methylenic carbon of various secondary amides, including lactams and azasteroids. This process involves reacting the amide with trialkylsilyl-X in the presence of iodine or bromine, leading to the formation of .alpha.-iodo- or .alpha.-bromo-amides that can be further transformed into .alpha.,.beta.-unsaturated amides through dehydrohalogenation.
Career Highlights
Newton L Abramson is currently employed at Merck & Company, Inc., where he continues to innovate and contribute to the field of chemistry. His work has been instrumental in advancing chemical processes that have practical applications in drug development and synthesis.
Collaborations
Throughout his career, Abramson has collaborated with esteemed colleagues such as Sandor Karady and Anthony O King. These collaborations have further enriched his research and development efforts, leading to groundbreaking advancements in chemical methodologies.
Conclusion
Newton L Abramson is a distinguished inventor whose contributions to chemical processes have significantly influenced the pharmaceutical industry. His innovative patents and collaborative efforts exemplify his commitment to advancing scientific knowledge and practical applications in chemistry.