This inventor holds 5 USPTO granted patents. Top assignee: California Institute of Technology. Active years: 2008-2017.
Company Filing History:
Years Active: 2008-2017
Title: Nelly Khidekel: Innovator in Protein Glycosylation Detection
Introduction
Nelly Khidekel is a prominent inventor based in Pasadena, CA (US). She has made significant contributions to the field of biochemistry, particularly in the detection of protein glycosylation. With a total of 5 patents, her work has the potential to impact various medical fields.
Latest Patents
One of her latest patents focuses on methods and compositions for the rapid and sensitive detection of post-translationally modified proteins. This invention is particularly aimed at detecting proteins with posttranslational glycosylations, specifically O-GlcNAc modifications. The method utilizes an engineered mutant of β-1,4-galactosyltransferase to transfer an unnatural ketone functionality onto O-GlcNAc glycosylated proteins. This ketone moiety serves as a versatile handle for biotin attachment, enabling the detection of modified proteins. The approach allows for the rapid visualization of proteins that are typically at the limits of detection using traditional methods. Furthermore, this invention can be applied to detect various disease states, including cancer, Alzheimer's disease, neurodegeneration, cardiovascular disease, and diabetes.
Career Highlights
Nelly Khidekel is affiliated with the California Institute of Technology, where she continues her research and innovation in biochemistry. Her work has garnered attention for its potential applications in medical diagnostics and therapeutic development.
Collaborations
Some of her notable coworkers include Sabine Arndt and Hwan-Ching Tai, who contribute to her research endeavors.
Conclusion
Nelly Khidekel's innovative work in the detection of protein glycosylation represents a significant advancement in biochemistry. Her contributions have the potential to enhance our understanding and treatment of various diseases.