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Years Active: 2010-2013
Title: Neil L Kelleher: Innovator in Mass Spectrometry
Introduction
Neil L Kelleher is a prominent inventor based in Urbana, IL (US). He has made significant contributions to the field of mass spectrometry, particularly in the area of isotopic labeling reagents. With a total of 3 patents, Kelleher's work has advanced the methods used for the relative quantification of metabolites.
Latest Patents
Kelleher's latest patents focus on ionizable isotopic labeling reagents for relative quantification by mass spectrometry. His work involves the relative quantification of metabolites using Electrospray Ionization Mass Spectrometry (ESI-MS). This innovative approach requires a mechanism for simultaneous analysis of multiple analytes in two or more samples. The labeling reagents he developed are reactive to specific compound classes and differ only in their isotopic compositions, facilitating relative quantification. Heavy and light isotopic forms of methylacetimidate, formaldehyde, and cholamine were synthesized and utilized as labeling reagents for quantifying amine-containing and carboxylic acid-containing molecules found in biological samples. The labeled end-products are positively charged under normal acidic conditions, which enhances sensitivity and accuracy in mass-spectra analysis.
Career Highlights
Throughout his career, Kelleher has worked with notable organizations, including the Wisconsin Alumni Research Foundation and the University of Illinois. His innovative contributions have significantly impacted the field of mass spectrometry and metabolomics.
Collaborations
Kelleher has collaborated with esteemed colleagues such as Lloyd M Smith and Michael Robert Shortreed. These collaborations have further enriched his research and development efforts in the field.
Conclusion
Neil L Kelleher's work in mass spectrometry and isotopic labeling has paved the way for advancements in metabolite quantification. His innovative patents and collaborations highlight his significant contributions to science and technology.