Neethan A Lobo

Title: Neethan A Lobo: Innovator in Cancer Research

Introduction

Neethan A Lobo is a prominent inventor based in Stanford, CA. He has made significant contributions to the field of cancer research through his innovative patents. His work focuses on understanding and manipulating biological pathways that are crucial in cancer progression.

Latest Patents

Neethan A Lobo holds 2 patents. His latest patents include "Compositions and methods for modulating left-right differentiation factor (LEFTY) and bone morphogenic factor (BMP)." This disclosure provides data showing that LEFTY inhibits differentiation-promoting pathways such as BMP7/pSMAD5 in breast cancer cell lines, over and above its known role of inhibiting Nodal/pSMAD2. LEFTY competes with BMP7 to bind to its cell surface receptor BMPR2, leading to inhibition of pSMAD5. The LEFTY-BMPR2 interaction is dominant over BMP-BMPR2 in tumorigenic cells, resulting in diminished pSMAD status. In non-tumorigenic cells, there is minimal LEFTY-BMPR2 interaction, increased BMP7-BMPR2 association, and elevated pSMAD. Additionally, he has developed compositions and methods for inducing or inhibiting expression and/or the activity of LEFTY and BMP proteins, which can be used in the diagnosis and therapy of cancer and other conditions, as well as to promote the proliferation of stem cells.

Career Highlights

Neethan A Lobo has worked with esteemed institutions such as Leland Stanford Junior University and Cz Biohub SF, LLC. His research has significantly advanced the understanding of cancer biology and therapeutic strategies.

Collaborations

Some of his notable coworkers include Michael F Clarke and Stephen R Quake. Their collaborative efforts have contributed to groundbreaking research in the field.

Conclusion

Neethan A Lobo is a key figure in cancer research, with innovative patents that have the potential to transform therapeutic approaches. His work continues to inspire advancements in medical science and treatment methodologies.