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For the Inventor, By the Inventor

Burlington, MA, United States of America

Naveen P Srivastava

USPTO Granted Patents = 10 


 

Average Co-Inventor Count = 2.7

ph-index = 3

Forward Citations = 19(Granted Patents)


Company Filing History:

goldMedal10 out of 21 
 
Chemgenes Corporation
 patents

Years Active: 2011-2019

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10 patents (USPTO):
1. 10167308 - Highly efficient synthesis of long RNA using reverse direction approach (2019-01-01),
2. 9884885 - Synthesis of labile base protected-modified deoxy and modified ribo nucleosides, corresponding phosphoramidites and supports and their use in high purity oligonucleotide synthesis (2018-02-06),
3. 9605261 - RNA synthesis—phosphoramidites for synthetic RNA in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic RNA at the 3'-end (2017-03-28),
4. 8981076 - Synthesis of N-FMOC protected deoxy nucleosides, ribo nucleosides, modified deoxy and ribo nucleosides, and phosphoramidites, and their use in oligonucleotide synthesis (2015-03-17),
5. 8933214 - RNA synthesis—phosphoramidites for synthetic RNA in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic RNA at the 3'-end (2015-01-13),
6. 8618279 - Synthesis of 2',3′— and 3′,5′—cyclic phosphate mono-and oligonucleotides (2013-12-31),
7. 8541569 - Phosphoramidites for synthetic RNA in the reverse direction, efficient RNA synthesis and convenient introduction of 3'-end ligands, chromophores and modifications of synthetic RNA (2013-09-24),
8. 8530634 - Method of oligonucleotide labeling using cycloaddition reaction (2013-09-10),
9. 8309707 - RNA synthesis-phosphoramidites for synthetic RNA in the reverse direction, and application in convenient introduction of ligands, chromophores and modifications of synthetic RNA at the 3'-end (2012-11-13),
10. 7956169 - Synthesis of novel azo-dyes and their use in oligonucleotide synthesis (2011-06-07),

Title: Innovator Naveen P. Srivastava: Pioneering RNA Synthesis

Introduction

Naveen P. Srivastava is a prominent inventor based in Burlington, MA (US), recognized for his significant contributions to the field of RNA synthesis. With an impressive portfolio that includes ten patents, Srivastava's work is shaping the future of molecular biology and therapeutic developments.

Latest Patents

Among his latest innovations, Srivastava has developed a highly efficient method for synthesizing long RNA using a reverse direction approach. This method showcases a novel process for the reverse 5'→3' directed synthesis of RNA oligomers, ranging from 100-mer to 200-mer. The synthesis achieved high quality with a coupling efficiency approaching 99%, paving the way for advancements in RNA applications.

Another noteworthy patent involves the synthesis of labile base protected-modified deoxy and modified ribonucleosides, alongside their corresponding phosphoramidites and supports. This invention utilizes N-2-acetyl protected guanine as a nucleoside base, which offers a faster and more stable option compared to traditional methods. The approach leads to high purity RNA and DNA oligonucleotides, ideal for therapeutic and diagnostic applications. The efficient removal of protecting groups under mild conditions further ensures the production of high purity oligonucleotides suitable for clinical use.

Career Highlights

Working at Chemgenes Corporation, Naveen Srivastava has established himself as an expert in the field of oligonucleotide synthesis. His innovative techniques have gained recognition in the scientific community, contributing to developments that impact both diagnostics and therapeutic strategies in molecular biology.

Collaborations

Throughout his career, Srivastava has worked alongside notable colleagues, including Suresh C. Srivastava and Andrei Laikhter. These collaborations have further enhanced the impact of his inventions, bringing together diverse expertise to tackle complex challenges in RNA synthesis.

Conclusion

Naveen P. Srivastava exemplifies the spirit of innovation through his groundbreaking work in RNA synthesis. His patents not only advance scientific knowledge but also hold the potential for significant improvements in therapeutic solutions. With his continued efforts at Chemgenes Corporation and collaborative partnerships, the future of RNA technology looks promising.

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