The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 13, 2015
Filed:
Oct. 02, 2012
Applicant:
Chemgenes Corporation, Wilmington, MA (US);
Inventors:
Suresh C Srivastava, Burlington, MA (US);
Divya Pandey, Lucknow, IN;
Satya P Bajpal, Lucknow, IN;
Naveen P Srivastava, Burlington, MA (US);
Assignee:
ChemGenes Corporation, Wilmington, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07H 21/00 (2006.01); C07H 21/04 (2006.01); C07H 1/00 (2006.01); C07H 19/067 (2006.01); C07H 19/167 (2006.01); C07H 21/02 (2006.01);
U.S. Cl.
CPC ...
C07H 1/00 (2013.01); C07H 19/067 (2013.01); C07H 19/167 (2013.01); C07H 21/02 (2013.01);
Abstract
The present invention relates to novel phosphoramidites, A-n-bz, C-n-bz, C-n-ac, G-n-ac and U are produced with an HPLC purity of greater than 98% andP NMR purity greater than 99%. A novel process of reverse 5'→3′ directed synthesis of RNA oligomers has been developed and disclosed. Using that method demonstrated high quality RNA synthesis with coupling efficiency approaching 99%.