Nathan Fischel-Ghodsian

Title: Nathan Fischel-Ghodsian: Innovator in Genetic Research

Introduction

Nathan Fischel-Ghodsian is a notable inventor based in Los Angeles, CA. He has made significant contributions to the field of genetic research, particularly in understanding familial Mediterranean fever and ototoxic deafness. With a total of 2 patents, his work has implications for both diagnosis and treatment of these conditions.

Latest Patents

Fischel-Ghodsian's latest patents include groundbreaking inventions related to the Pyrin gene and its mutants, which are associated with familial Mediterranean fever (FMF). The invention provides the nucleic acid sequence encoding the protein linked to FMF, designated as MEFV. It also encompasses fragments of the DNA sequence, the corresponding RNA transcript, and the amino acid sequence for the pyrin protein. Notably, the invention identifies three missense mutations within the highly conserved rfp (B30.2) domain of the protein, including M6801, M694V, K695R, and V726A. Additionally, it outlines methods for diagnosing patients at risk for FMF and includes kits for such diagnoses. Another significant patent involves a method for detecting mitochondrial nucleotide predispositions for ototoxic deafness, particularly related to aminoglycoside administration.

Career Highlights

Throughout his career, Nathan Fischel-Ghodsian has worked with esteemed institutions, including Cedars-Sinai Medical Center. His research has contributed to advancements in genetic understanding and patient care.

Collaborations

Fischel-Ghodsian has collaborated with notable colleagues such as Toni Rita Prezant and Daniel L Kastner, enhancing the impact of his research through teamwork and shared expertise.

Conclusion

Nathan Fischel-Ghodsian's innovative work in genetic research has led to important patents that advance our understanding of familial Mediterranean fever and ototoxic deafness. His contributions continue to influence the field and improve patient outcomes.