Location History:
- Toulouse Cedex, FR (2015)
- Toulouse, FR (2017 - 2023)
Company Filing History:
3 out of 1,743 
2 out of 61 
2 out of 14 
Years Active: 2015-2023
Title: Nathalie Vergnolle: Innovator in Gut Inflammatory Disease Therapies
Introduction
Nathalie Vergnolle is a prominent inventor based in Toulouse, France. She has made significant contributions to the field of therapy for gut inflammatory diseases. With a total of 4 patents, her work focuses on innovative methods to treat conditions such as Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS).
Latest Patents
Nathalie's latest patents include a method of treating inflammatory bowel disease (IBD), irritable bowel syndrome (IBS), or gluten hypersensitivity by administering an elastase 2A (ELA2A) inhibitor. This invention addresses the therapy of gut inflammatory diseases, demonstrating that ELA2A, secreted by epithelial cells, is over-expressed in IBD conditions. This overexpression degrades tight junction proteins and controls cytokine expression, leading to a pro-inflammatory phenotype. The research shows that intestinal epithelial cells overexpressing ELA2A increase the release of CXCL8 protein compared to control cells. Furthermore, the increased CXCL-8 protein release is inhibited by ELAFIN in a dose-dependent manner. The invention particularly relates to inhibitors of Elastase ELA2A for treating various inflammatory bowel diseases, including Crohn's Disease, Ulcerative Colitis, Celiac disease, and Pouchitis.
Career Highlights
Nathalie has worked with esteemed organizations such as the National Institute of Health and Medical Research (INSERM) and the National Institute for Agricultural Research (INRA). Her research has significantly advanced the understanding and treatment of gut inflammatory diseases.
Collaborations
Nathalie has collaborated with notable colleagues, including Corinne Rolland and Céline Deraison-Manuel. These partnerships have further enriched her research and contributions to the field.
Conclusion
Nathalie Vergnolle's innovative work in the treatment of gut inflammatory diseases showcases her dedication to advancing medical therapies. Her patents and collaborations reflect her significant impact on the field, making her a key figure in the ongoing fight against these challenging conditions.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.